Douglas J W, Gear R
Arch Dis Child. 1976 Nov;51(11):820-7. doi: 10.1136/adc.51.11.820.
Among 12 468 legitimate single births in the first week of March 1946, 163 weighed 200 g or less (LBW group) and of these 80 survived to 18 years. 6 of the LBW survivors emigrated with their families and 5 have not been traced since birth. The remaining 69 were followed up to the age of 15 at which time two early school leavers were lost to the study. There is evidence that none of the survivors who emigrated or left the sample and serious physical or mental impairment. Compared with individually matched controls, the LBW children showed similar proportions with severe physical, mental, or behavioural handicaps. There are small and statistically nonsignificant differences in favour of the controls in ability and attainment scores at 15 years and in the level of academic qualifications gained by the age of 18. If the mean ability and attainment scores are expressed as an "intelligence quotient" with a mean of 100 and a standard deviation of 15, the LBW group has an average IQ of 93 and the controls of 97. Hospital stay after childbirth was much longer in 1946 than today and many LBW children spent more than 3 weeks in hospital. There is no evidence that long hospital stay was associated with problems of behaviour or learning in adolescence.
在1946年3月第一周的12468例合法单胎分娩中,163例出生体重小于或等于200克(低体重组),其中80例存活至18岁。低体重组的80名存活者中有6名随家人移民,5名自出生后便失去踪迹。其余69名被随访至15岁,当时有两名过早辍学,失去联系。有证据表明,移民或失访的幸存者均未出现严重的身体或精神损伤。与个体匹配的对照组相比,低体重儿童出现严重身体、精神或行为障碍的比例相似。在15岁时的能力和成绩得分以及18岁时获得的学历水平方面,对照组略占优势,但差异较小且无统计学意义。如果将平均能力和成绩得分表示为“智商”,平均分为100,标准差为15,那么低体重组的平均智商为93,对照组为97。1946年产后住院时间比现在长得多,许多低体重儿童住院时间超过3周。没有证据表明长时间住院与青少年期的行为或学习问题有关。