Nakae H, Asada S
Kobe Women's College of Pharmacy, Motoyama Kitamachi, Japan.
Chem Pharm Bull (Tokyo). 1992 Mar;40(3):821-2. doi: 10.1248/cpb.40.821.
Proliferation of human leukemia cells, HL60, was synergistically inhibited by a combination of human interferons and azidothymidine in vitro. Combination of interferon-gamma (3000 U/ml) and azidothymidine (30 microM) inhibited cell growth by 76%, whereas interferon-gamma alone suppressed growth by 23% and azidothymidine alone by 33%. Interferon-alpha-2a and interferon-beta also exerted synergistic effects with azidothymidine, but the potentiation was weaker than that by the combination of interferon-gamma and aziodthymidine.
