Hilliker C, Van Leuven F, Van den Berghe H
Center for Human Genetics, University of Leuven, Belgium.
Genomics. 1992 Jun;13(2):472-4. doi: 10.1016/0888-7543(92)90276-x.
The assignment of the gene encoding the alpha 2-macroglobulin receptor (A2MR), which was first described as the low-density lipoprotein receptor-related protein, was confirmed by nonisotopic and isotopic in situ hybridizations on normal human metaphases to the region 12q13-q14. The same human cDNA, which has 95% sequence identity with the mouse A2mr, was hybridized to metaphases containing the Robertsonian translocation Rb(6;15)1Ald. The mouse A2mr gene was assigned to chromosome 15 in the region B2-D1. This locus and other loci on mouse chromosome 15 have been shown to be homologous with loci on human chromosome 12q.
编码α2-巨球蛋白受体（A2MR）的基因最初被描述为低密度脂蛋白受体相关蛋白，通过对正常人中期染色体进行非同位素和同位素原位杂交，证实该基因定位于12q13 - q14区域。将与小鼠A2mr具有95%序列同一性的相同人类cDNA与含有罗伯逊易位Rb(6;15)1Ald的中期染色体杂交。小鼠A2mr基因定位于15号染色体上的B2 - D1区域。已证明该位点以及小鼠15号染色体上的其他位点与人类12号染色体q臂上的位点同源。
