Pannarale G, Puddu P E, Campbell S V, Collauto F, Stazi F, Reale A
II Cattedra di Malattie dell'Apparato Cardiovascolare, Università La Sapienza, Rome, Italy.
J Cardiovasc Pharmacol. 1992;19 Suppl 2:S53-6. doi: 10.1097/00005344-199219002-00013.
The aim of the present study was to compare the effects of slow-release verapamil (V), 240 mg and nitrendipine (N), 20 mg, administered once daily, on office (OBP) and 24-h ambulatory blood pressure (ABP) in patients with mild-to-moderate hypertension. Twenty patients were entered into this open, randomized, two-group (V, N) parallel study. The study groups had similar age and sex distribution. The OBP (V, 155/103 +/- 19/8 mm Hg; N, 141/98 +/- 13/4 mm Hg), heart rate (HR) (V, 74 +/- 7 beats/min; N, 77 +/- 10 beats/min), daytime systolic ABP (V, 149 +/- 14 mm Hg; N, 147 +/- 13 mm Hg), and nighttime ABP of the two groups were not statistically different after a 2-week washout period. The daytime diastolic ABP (V, 99 +/- 6 mm Hg; N, 93 +/- 6 mm Hg) was slightly lower (p less than 0.05) in group N. Both the OBP (V, 136/90 +/- 19/9 mm Hg; N, 135/85 +/- 10/4 mm Hg) and daytime ABP (V, 132/85 +/- 14/4 mm Hg; N, 136/87 +/- 13/8 mm Hg) dropped in the two groups after 8 weeks of treatment. Nonparametric analysis did not show statistical differences between the groups in OBP and ABP percentage drop. There was no significant change in nighttime ABP, HR (V, 73 +/- 10 beats/min; N, 74 +/- 12 beats/min), ECG, and laboratory exams. We conclude that both verapamil SR and nitrendipine are effective in reducing blood pressure in hypertensive patients without altering the HR.
本研究旨在比较每日一次服用240毫克缓释维拉帕米（V）和20毫克尼群地平（N）对轻至中度高血压患者诊室血压（OBP）和24小时动态血压（ABP）的影响。20名患者进入了这项开放、随机、两组（V、N）平行研究。研究组的年龄和性别分布相似。经过2周的洗脱期后，两组的OBP（V组，155/103±19/8毫米汞柱；N组，141/98±13/4毫米汞柱）、心率（HR）（V组，74±7次/分钟；N组，77±10次/分钟）、日间收缩期ABP（V组，149±14毫米汞柱；N组，147±13毫米汞柱）和夜间ABP无统计学差异。N组的日间舒张期ABP（V组，99±6毫米汞柱；N组，93±6毫米汞柱）略低（p<0.05）。治疗8周后，两组的OBP（V组，136/90±19/9毫米汞柱；N组，135/85±10/4毫米汞柱）和日间ABP（V组，132/85±14/4毫米汞柱；N组，136/87±13/8毫米汞柱）均下降。非参数分析未显示两组在OBP和ABP下降百分比方面有统计学差异。夜间ABP、HR（V组，73±10次/分钟；N组，74±12次/分钟）、心电图和实验室检查均无显著变化。我们得出结论，缓释维拉帕米和尼群地平在降低高血压患者血压方面均有效，且不改变心率。
