文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Tanaka K, Inoue T, Kadota S, Kikuchi T

National Research Institute of Police Science, Tokyo, Japan.

Xenobiotica. 1992 Jan;22(1):33-9. doi: 10.3109/00498259209053100.

Enzyme systems responsible for formation of cyclopropane ring-cleavage metabolites (M1 and M2) of illudin S in rat liver were characterized. 2. The enzymes were localized in the cytosol fraction and utilized NADPH alone as electron donor; they were not affected by oxygen and had low pH optima. 3. Formation of metabolites M1 and M2 was inhibited completely by dicumarol (10(-4) M), an inhibitor of DT-diaphorase. 4. Menadione (10(-4) M) and quercetin (10(-4) M) both inhibited formation of M1 and M2 by 35% and 15%, respectively, but quinacrine, barbital, pyrazole and p-chloromercuribenzoic acid had no significant effect. 5. Results show that the enzyme systems may differ from DT-diaphorase, aldehyde oxidase, xanthine oxidase, ketone reductase, aldose reductase, aldehyde reductase and alcohol dehydrogenase, known cytosolic enzymes responsible for xenobiotic metabolism.

对大鼠肝脏中负责鬼笔环肽S环丙烷环裂解代谢物（M1和M2）形成的酶系统进行了表征。2. 这些酶定位于胞质溶胶部分，仅以NADPH作为电子供体；它们不受氧气影响，最适pH较低。3. 代谢物M1和M2的形成被双香豆素（10^(-4) M）完全抑制，双香豆素是DT-黄递酶的抑制剂。4. 甲萘醌（10^(-4) M）和槲皮素（10^(-4) M）分别使M1和M2的形成抑制35%和15%，但奎纳克林、巴比妥、吡唑和对氯汞苯甲酸没有显著影响。5. 结果表明，该酶系统可能不同于DT-黄递酶、醛氧化酶、黄嘌呤氧化酶、酮还原酶、醛糖还原酶、醛还原酶和醇脱氢酶，这些是已知的负责异源生物代谢的胞质酶。

Tanaka K, Inoue T, Kadota S, Kikuchi T

National Research Institute of Police Science, Tokyo, Japan.

Xenobiotica. 1992 Jan;22(1):33-9. doi: 10.3109/00498259209053100.

Enzyme systems responsible for formation of cyclopropane ring-cleavage metabolites (M1 and M2) of illudin S in rat liver were characterized. 2. The enzymes were localized in the cytosol fraction and utilized NADPH alone as electron donor; they were not affected by oxygen and had low pH optima. 3. Formation of metabolites M1 and M2 was inhibited completely by dicumarol (10(-4) M), an inhibitor of DT-diaphorase. 4. Menadione (10(-4) M) and quercetin (10(-4) M) both inhibited formation of M1 and M2 by 35% and 15%, respectively, but quinacrine, barbital, pyrazole and p-chloromercuribenzoic acid had no significant effect. 5. Results show that the enzyme systems may differ from DT-diaphorase, aldehyde oxidase, xanthine oxidase, ketone reductase, aldose reductase, aldehyde reductase and alcohol dehydrogenase, known cytosolic enzymes responsible for xenobiotic metabolism.

对大鼠肝脏中负责鬼笔环肽S环丙烷环裂解代谢物（M1和M2）形成的酶系统进行了表征。2. 这些酶定位于胞质溶胶部分，仅以NADPH作为电子供体；它们不受氧气影响，最适pH较低。3. 代谢物M1和M2的形成被双香豆素（10^(-4) M）完全抑制，双香豆素是DT-黄递酶的抑制剂。4. 甲萘醌（10^(-4) M）和槲皮素（10^(-4) M）分别使M1和M2的形成抑制35%和15%，但奎纳克林、巴比妥、吡唑和对氯汞苯甲酸没有显著影响。5. 结果表明，该酶系统可能不同于DT-黄递酶、醛氧化酶、黄嘌呤氧化酶、酮还原酶、醛糖还原酶、醛还原酶和醇脱氢酶，这些是已知的负责异源生物代谢的胞质酶。