酰基富烯，一类新型强效抗肿瘤药物。
Acylfulvenes, a new class of potent antitumor agents.
作者信息
McMorris T C, Kelner M J, Wang W, Diaz M A, Estes L A, Taetle R
机构信息
Department of Chemistry, University of California, San Diego, La Jolla 92093-0506, USA.
出版信息
Experientia. 1996 Jan 16;52(1):75-80. doi: 10.1007/BF01922420.
PMID:8575564
Abstract
Acylfulvene, derived from the sesquiterpene illudin S by treatment with acid (reverse Prins reaction), is far less reactive to thiols than illudin S. However, it is reduced readily to an aromatic product, in the same way as illudin S. This may explain its greatly improved therapeutic index compared to that of the parent compound.
摘要
酰基富烯是通过用酸处理倍半萜伊利菌素S（逆普林斯反应）得到的，它与硫醇的反应活性比伊利菌素S低得多。然而，它与伊利菌素S一样，很容易被还原为芳香产物。这可能解释了它与母体化合物相比，治疗指数有了很大提高。
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