吗啡对离体豚鼠空肠肾上腺素能神经的作用。
The effect of morphine on the adrenergic nerves of the isolated guinea-pig jejunum.
作者信息
SZERB J C
出版信息
Br J Pharmacol Chemother. 1961 Feb;16(1):23-31. doi: 10.1111/j.1476-5381.1961.tb00294.x.
Abstract
Nerves accompanying the mesenteric blood-vessels of the isolated guinea-pig jejunum were stimulated and changes in the longitudinal muscle coat were recorded. Stimulation of the nerves led to a rapid relaxation if the intestine was contracted by a previous administration of histamine. The relaxation was inhibited by morphine and partially restored by nalorphine. Bretylium and atropine also inhibited the relaxation and cocaine increased it somewhat. Morphine, atropine, and bretylium had no significant effect on the depressant action of noradrenaline on histamine contractions, whereas cocaine slightly enhanced the action of noradrenaline. Morphine, but not the other drugs, prevented the inhibitory action of dopamine.
摘要
刺激分离的豚鼠空肠系膜血管伴行神经，并记录纵肌层的变化。如果肠道因先前给予组胺而收缩，刺激神经会导致快速松弛。吗啡可抑制这种松弛，而烯丙吗啡可部分恢复。溴苄铵和阿托品也抑制松弛，可卡因则使其有所增强。吗啡、阿托品和溴苄铵对去甲肾上腺素对组胺收缩的抑制作用无显著影响，而可卡因可轻微增强去甲肾上腺素作用。吗啡而非其他药物可阻止多巴胺的抑制作用。
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