多巴胺和肾上腺素的降压作用。
The depressor action of dopamine and adrenaline.
作者信息
BURN J H, RAND M J
出版信息
Br J Pharmacol Chemother. 1958 Dec;13(4):471-9. doi: 10.1111/j.1476-5381.1958.tb00240.x.
Dopamine is a pressor agent in the spinal cat, but causes a fall of blood pressure in the guinea-pig and rabbit under urethane anaesthesia. When guinea-pigs and rabbits are injected with reserpine, which depletes the vessel walls of noradrenaline, dopamine then becomes pressor. If an intravenous infusion of noradrenaline is given the depressor action returns. An intravenous infusion of vasopressin does not have this effect.A strip of rabbit aorta is caused to contract by noradrenaline and by dopamine, but if dopamine is added at the height of a noradrenaline contraction it causes relaxation.Adrenaline causes a fall of blood pressure in the cat under ether with vagi cut. However, in a reserpine-treated cat its action is pressor. The depressor action is restored during an infusion of noradrenaline. Noradrenaline has thus been shown to cause a vasomotor reversal of dopamine and of adrenaline.
多巴胺对脊髓麻醉猫是一种升压剂，但在氨基甲酸乙酯麻醉下，对豚鼠和兔子会引起血压下降。当给豚鼠和兔子注射利血平（它会耗尽血管壁中的去甲肾上腺素）后，多巴胺就会变成升压剂。如果静脉输注去甲肾上腺素，降压作用就会恢复。静脉输注血管加压素则没有这种效果。兔主动脉条会因去甲肾上腺素和多巴胺而收缩，但如果在去甲肾上腺素收缩达到高峰时加入多巴胺，它会导致舒张。在切断迷走神经的乙醚麻醉下，肾上腺素会使猫的血压下降。然而，在经利血平处理的猫中，其作用是升压的。在输注去甲肾上腺素期间，降压作用会恢复。因此，已证明去甲肾上腺素会引起多巴胺和肾上腺素的血管运动反转。
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