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皮质类固醇对大鼠体内组胺和5-羟色胺代谢的某些影响。

Some effects of corticosteroids on the metabolism of histamine and 5-hydroxytryptamine in the rat.

作者信息

TELFORD J M, WEST G B

出版信息

Br J Pharmacol Chemother. 1961 Jun;16(3):360-8. doi: 10.1111/j.1476-5381.1961.tb01096.x.

Abstract

Daily intramuscular injections of cortisone, prednisolone, triamcinolone, fludrocortisone and 2-methylfludrocortisone reduced the histidine decarboxylase activity of the rat liver, but increased the enzyme activity of the pyloric stomach. Injections of histamine liberators or exposure to cold produced similar changes. After adrenalectomy, the histidine decarboxylase activities of the liver and pyloric stomach were unaltered, but the histaminase activity of the ileum was reduced. The 5-hydroxytryptophan decarboxylase activities of rat liver and kidney were not altered by treatment with corticosteroids.

摘要

每日肌肉注射可的松、泼尼松龙、曲安奈德、氟氢可的松和2-甲基氟氢可的松会降低大鼠肝脏的组氨酸脱羧酶活性,但会增加幽门胃的该酶活性。注射组胺释放剂或暴露于寒冷环境也会产生类似变化。肾上腺切除术后,肝脏和幽门胃的组氨酸脱羧酶活性未改变,但回肠的组胺酶活性降低。皮质类固醇治疗不会改变大鼠肝脏和肾脏的5-羟色氨酸脱羧酶活性。

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