Pharoah P O
Br J Prev Soc Med. 1976 Dec;30(4):257-61. doi: 10.1136/jech.30.4.257.
Infants of birthweight up to 2500 g born in 1966 in two district hospitals were followed-up until their school medical examination at six years. Neonatal mortality rates differed in the two cohorts despite similar maternal age, parity, and social class distribution; differences in the management of labour and in neonatal care may have been responsible. Numbers were small but the prevalence of mild or more severe handicaps among the survivors did not differ significantly between the cohorts; an improved mortality was not achieved at the expense of an increased overall morbidity, although there was a suggestion of a difference in cerebral palsy prevalence. It is suggested that the neonatal mortality rate in conjunction with the prevalence of handicaps among the survivors of low birthweight infants be used as an indicator of the efficacy of perinatal care.
1966年在两家区级医院出生的出生体重达2500克的婴儿,一直随访到他们6岁时接受学校体检。尽管两个队列的产妇年龄、胎次和社会阶层分布相似,但新生儿死亡率却有所不同;分娩管理和新生儿护理方面的差异可能是原因所在。研究对象数量较少,但两个队列中幸存者中轻度或更严重残疾的患病率没有显著差异;虽然有迹象表明脑瘫患病率存在差异,但死亡率的改善并非以增加总体发病率为代价。建议将低体重儿幸存者中的新生儿死亡率与残疾患病率结合起来,作为围产期护理效果的一个指标。