P物质抑制孤束核中诱发的生物电反应：与γ-氨基丁酸能神经元的相互作用。

Substance P depresses bioelectrical responses evoked in the nucleus tractus solitarii: interaction with gamma-aminobutyric acid-ergic neurons.

作者信息

Pérez H, Ruiz S, Inostroza H, Perretta M

机构信息

Unit of Neurophysiology and Biophysics, University of Chile, Santiago.

出版信息

Eur J Pharmacol. 1992 Mar 31;213(3):435-7. doi: 10.1016/0014-2999(92)90633-f.

DOI:10.1016/0014-2999(92)90633-f

PMID:1377632

Abstract

The effects of intracerebroventricular (i.c.v.) administration of substance P (SP) and gamma-aminobutyric acid (GABA) on responses evoked in the nucleus tractus solitarii (NTS) by electrical stimulation of the ipsilateral sinusal nerve were studied in alpha-chloralose-anesthetized rats. Both SP (0.01-10 micrograms) and GABA (100 micrograms) significantly depressed the presumably C-fiber mediated, late negative wave of the response. The effects were almost completely prevented by bicuculline (10 micrograms i.c.v.). It is concluded that i.c.v. administered SP induces dose-dependent depression of baro- and/or chemosensory transmission in the NTS, via a mechanism involving interactions with GABAergic neurons of the NTS.

摘要

在α-氯醛糖麻醉的大鼠中，研究了脑室内（i.c.v.）注射P物质（SP）和γ-氨基丁酸（GABA）对同侧窦神经电刺激诱发的孤束核（NTS）反应的影响。SP（0.01 - 10微克）和GABA（100微克）均显著抑制了推测由C纤维介导的反应晚期负波。荷包牡丹碱（脑室内注射10微克）几乎完全阻断了这些效应。得出的结论是，脑室内注射的SP通过一种涉及与NTS中GABA能神经元相互作用的机制，诱导NTS中压力和/或化学感觉传递的剂量依赖性抑制。