Lukovic L, de Jong W, de Wied D
Institute of Experimental Pharmacology, Centre Slovak Academy of Sciences, Bratislava.
Brain Res. 1987 Oct 6;422(2):312-8. doi: 10.1016/0006-8993(87)90938-3.
This report deals with the effect of substance P (SP) and capsaicin on blood pressure and heart rate after administration into different sites of the nucleus tractus solitarii (NTS) of urethane-anesthetized rats. Microinjection of SP at 6 different coordinates throughout the NTS showed 3 sites where SP administration evoked changes in blood pressure and heart rate. The most sensitive sites where application of SP into the NTS evoked dose-dependent hypotension and bradycardia were at the level of the posterior tip of the area postrema (zero level) and at the level of the obex. Capsaicin evoked dose-dependent hypotension and bradycardia at the same sites. These results further support the possibility that SP may be a neurotransmitter or neuromodulator of baroreceptor afferents in the NTS.
本报告探讨了在氨基甲酸乙酯麻醉的大鼠孤束核（NTS）不同部位注射P物质（SP）和辣椒素后对血压和心率的影响。在整个NTS的6个不同坐标处微量注射SP，结果显示有3个部位注射SP后可引起血压和心率变化。将SP注入NTS引起剂量依赖性低血压和心动过缓的最敏感部位位于最后区后尖端水平（零水平）和闩水平。辣椒素在相同部位引起剂量依赖性低血压和心动过缓。这些结果进一步支持了SP可能是NTS中压力感受器传入神经的神经递质或神经调节剂的可能性。
