Gardiner S M, Kemp P A, Bennett T, Palmer R M, Moncada S
Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen's Medical Centre, U.K.
Eur J Pharmacol. 1992 Mar 31;213(3):449-51. doi: 10.1016/0014-2999(92)90636-i.
Homozygous male Brattleboro rats were given a solution of NG-monomethyl-L-arginine (L-NMMA; 1 mg ml-1) to drink for a period of 7 days. There was a persistent elevation of mean arterial blood pressure, accompanied by a significant hindquarters vasoconstriction. Within 9 h of withdrawal of L-NMMA all variables were not different from pre-L-NMMA values. Brattleboro rats (n = 3) which had been drinking NG-nitro-L-arginine methyl ester (L-NAME) solution (0.05 mg ml-1) for 5-6 months showed an increased blood pressure which reversed to normal within 48 h after withdrawing the L-NAME. Thus, inhibition of nitric oxide synthesis leads to long-lasting, but reversible, hypertension.
给纯合子雄性布拉特洛伯大鼠饮用浓度为1毫克/毫升的NG-单甲基-L-精氨酸（L-NMMA）溶液，持续7天。平均动脉血压持续升高，同时伴有后肢显著血管收缩。停用L-NMMA后9小时内，所有变量与使用L-NMMA前的值无差异。饮用浓度为0.05毫克/毫升的NG-硝基-L-精氨酸甲酯（L-NAME）溶液5至6个月的布拉特洛伯大鼠（n = 3）血压升高，停用L-NAME后48小时内血压恢复正常。因此，一氧化氮合成的抑制会导致持久但可逆的高血压。
