慢性乙醇喂养大鼠中线粒体RNA转录本的特异性增加。
Specific increase of a mitochondrial RNA transcript in chronic ethanol-fed rats.
作者信息
Enríquez J A, Pérez-Martos A, Fernández-Silva P, López-Pérez M J, Montoya J
机构信息
Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Universidad de Zaragoza, Spain.
出版信息
FEBS Lett. 1992 Jun 15;304(2-3):285-8. doi: 10.1016/0014-5793(92)80639-x.
An in vitro transcription system utilizing isolated mitochondria has been used to study the effect of chronic ethanol consumption on liver mitochondrial DNA transcription. The results obtained showed an overall increase of RNA synthesis and a dramatic accumulation of a discrete polyadenylated RNA species. This effect is a consequence of the chronic ethanol consumption since these changes do not occur when isolated control mitochondria are incubated in the presence of ethanol.
利用分离的线粒体的体外转录系统已被用于研究长期乙醇摄入对肝脏线粒体DNA转录的影响。所获得的结果显示RNA合成总体增加，并且一种离散的多聚腺苷酸化RNA种类显著积累。这种效应是长期乙醇摄入的结果，因为当分离的对照线粒体在乙醇存在下孵育时，这些变化不会发生。
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