THULINE H C, NORBY D W
Science. 1961 Aug 25;134(3478):554-5. doi: 10.1126/science.134.3478.554.
A syndrome in male cats analogous to chromatin-positive Klinefelter's syndrome in human males has been demonstrated. The physical characteristics which suggested an abnormality of chromosome number in cats were "calico" or "tortoise-shell" coat colors in a male. Buccal mucosal smears were found to have "female-type" patterns in two out of 12 such male cats screened, and these two were found to have a diploid chromosome number of 39 rather than the normal 38. Testicular biopsy performed on one revealed an abnormal pattern; no gonadal tissue was found in the other cat with an abnormal chromosome number. These findings indicate that the cat, in addition to the mouse, is available for experimental study of chromosome number abnormalities.
已证实雄性猫中存在一种类似于人类男性染色质阳性克兰费尔特综合征的综合征。雄性猫呈现出“花斑”或“玳瑁”毛色，这表明其染色体数目异常。在筛查的12只此类雄性猫中，有2只的口腔黏膜涂片呈现出“雌性型”模式，并且这两只猫的二倍体染色体数目为39条，而非正常的38条。对其中一只进行睾丸活检，发现其模式异常；在另一只染色体数目异常的猫中未发现性腺组织。这些发现表明，除了小鼠之外，猫也可用于染色体数目异常的实验研究。
