Raasveld M H, Bloemena E, Surachno S, ten Berge R J
Clinical Immunology Laboratory, University of Amsterdam, The Netherlands.
Nephrol Dial Transplant. 1992;7(6):530-3.
T gamma/delta lymphocytes are able to perform allospecific cytotoxicity and natural killer cytotoxicity in vitro. However, very little is known about their function in vivo. To investigate the possible involvement of T gamma/delta lymphocytes in the immune response to renal allografts, fine-needle aspiration biopsies and peripheral blood of 15 renal transplant recipients were studied during the first 4 weeks after transplantation. In addition peripheral blood of patients before transplantation, half a year and one year after transplantation was studied. No increase in the percentage of T gamma/delta lymphocytes in the fine-needle aspiration biopsies, including those taken during acute rejection episodes, was found. A significant decrease in the percentage of T gamma/delta lymphocytes was observed in peripheral blood after transplantation. We conclude that T gamma/delta lymphocytes seem to play no major role in the immune response to renal allografts.
γ/δ T淋巴细胞在体外能够进行同种异体特异性细胞毒性和自然杀伤细胞毒性作用。然而，对于它们在体内的功能却知之甚少。为了研究γ/δ T淋巴细胞在肾移植免疫反应中可能发挥的作用，我们对15名肾移植受者在移植后的前4周进行了细针穿刺活检和外周血研究。此外，还研究了这些患者移植前、移植后半年和一年的外周血情况。在细针穿刺活检中，包括急性排斥反应发作期间采集的样本，均未发现γ/δ T淋巴细胞百分比增加。移植后外周血中γ/δ T淋巴细胞百分比显著下降。我们得出结论，γ/δ T淋巴细胞似乎在肾移植免疫反应中不发挥主要作用。
