Yang L P, Wen Z Y, Yu G Q, Tian H
Department of Physiology, Zunyi Medical College.
Sheng Li Xue Bao. 1992 Apr;44(2):192-6.
Using an electromagnetic flowmeter technique, the cardiac output as measured by blood flow in the aortic arch was measured during intracerebroventricular injection (icv.) of Substance P (SP) and physostigmine in 47 anesthetized rabbits. Carotid artery blood pressure and heart rate were recorded. After icv of SP (20 micrograms/20 microliters) or physostigmine (60 micrograms/20 microliters), both cardiac output and mean artery pressure were increased. Pretreatment with icv. of atropine (150 micrograms/20 microliters) did not alter the effect of SP, but the effect of physostigmine was blocked by pretreatment with SP blocker (25 micrograms/20 microliters). These findings suggest that cerebral SP is involved in cholinergic mechanisms on the central control of blood pressure.
采用电磁流量计技术，在47只麻醉兔脑室内注射（icv.）P物质（SP）和毒扁豆碱期间，测量主动脉弓血流所测得的心输出量。记录颈动脉血压和心率。脑室内注射SP（20微克/20微升）或毒扁豆碱（60微克/20微升）后，心输出量和平均动脉压均升高。脑室内注射阿托品（150微克/20微升）预处理并未改变SP的作用，但毒扁豆碱的作用被SP阻断剂（25微克/20微升）预处理所阻断。这些发现表明，脑内SP参与了血压中枢控制的胆碱能机制。
