Zhang X H, Yin G X, Ni H
Department of Physiology, Nanjing Medical University, Nanjing 210029.
Sheng Li Xue Bao. 1999 Apr;51(2):140-6.
Injection of neurotensin (NT) (10 and 20 micrograms/rat) into the lateral cerebroventricle (icv) could induce a rise or a drop of blood pressure and a slowing down of heart rate in urethane anaesthetized male rats (1.2 g/kg). The central pressor and depressor response to NT could be respectively blocked by pretreatment with alpha 1-receptor blocker prazosin (1.5 micrograms/3 microliters, icv) and M receptor blocker atropine (2.5 micrograms/3 microliters, icv). No significant changes in central cardiovascular responses to NT were observed following pretreatment with either H1 receptor blocker chlorpheniramin (50 micrograms/3 microliters, icv) or H2 receptor blocker cimetidine (250 micrograms/3 microliters, icv). In view of the above results it appears that NT, catecholamine and acetylcholine are all involved in central regulation of blood pressure.
向侧脑室（icv）注射神经降压素（NT）（10和20微克/大鼠）可使乌拉坦麻醉的雄性大鼠（1.2克/千克）的血压升高或降低，并使心率减慢。NT引起的中枢升压和降压反应可分别被α1受体阻滞剂哌唑嗪（1.5微克/3微升，icv）和M受体阻滞剂阿托品（2.5微克/3微升，icv）预处理所阻断。用H1受体阻滞剂氯苯那敏（50微克/3微升，icv）或H2受体阻滞剂西咪替丁（250微克/3微升，icv）预处理后，未观察到NT引起的中枢心血管反应有明显变化。鉴于上述结果，似乎NT、儿茶酚胺和乙酰胆碱均参与血压的中枢调节。
