Pirovino M
Medizinische Klinik, Kantonsspital Olten.
Ther Umsch. 1992 May;49(5):302-9.
The interferon treatment of chronic viral hepatitis leads to a measurable inhibition of replication of the various hepatitis viruses. In adult patients with chronic HBe-Ag-positive hepatitis B, the seroconversion rate is tripled by therapy when compared with untreated controls. In chronic hepatitis C, biochemical remission is achieved in about 50% of patients, but there is a high tendency to relapse. Interferon treatment has little effect in hepatitis B virus infection transmitted perinatally and in chronic delta hepatitis. Better knowledge of prognostic variables and deeper insights into the mechanisms of chronic hepatitis C virus infection should help both to increase rates and duration of remissions and to reduce the rates of relapse in the future.
慢性病毒性肝炎的干扰素治疗可对多种肝炎病毒的复制产生可测量的抑制作用。在慢性HBe-Ag阳性的成年乙型肝炎患者中，与未经治疗的对照组相比，治疗使血清学转换率提高了两倍。在慢性丙型肝炎中，约50%的患者实现了生化缓解，但复发倾向较高。干扰素治疗对围产期传播的乙型肝炎病毒感染和慢性丁型肝炎几乎没有效果。更好地了解预后变量以及对慢性丙型肝炎病毒感染机制有更深入的认识，应有助于提高缓解率和缓解持续时间，并在未来降低复发率。
