Shirakashi A
Department of Ophthalmology, Niigata University School of Medicine, Japan.
Nippon Ganka Gakkai Zasshi. 1992 May;96(5):677-82.
The natural history of 25 eyes of 21 patients with serous retinal pigment epithelial detachment (PED) within the vascular arcade was retrospectively studied to clarify the risk factors for development of choroidal neovascular membranes (NVM) from PED (mean age 55.8 +/- 10.4 years; mean follow-up 18.8 +/- 10.3 months). During the follow-up period, 6 eyes (24%) developed NVM. The significant risk factors for NVM development at the first visit were: older patient age (greater than 60 years): larger PED size (greater than 1 disc diameter): presence of PED in the fovea. Eyes with sensory retinal detachment that did not decrease during the follow-up had a significant high risk for NVM development. Eyes with NVM development showed significantly worse visual prognosis as compared to those with no NVM development. Life-table analysis (Kaplan-Meier method) showed that the incidence of developing NVM was 8% at 3 months, 16% at 6 months, and 24% at 9 months. These results suggested that the size and location of PED and clinical course of sensory retinal detachment in addition to the patient age may be important determinants of the prognosis of PED.
回顾性研究了21例视网膜血管弓内浆液性视网膜色素上皮脱离（PED）患者的25只眼的自然病史，以明确PED发展为脉络膜新生血管膜（NVM）的危险因素（平均年龄55.8±10.4岁；平均随访18.8±10.3个月）。在随访期间，6只眼（24%）发生了NVM。初诊时NVM发生的显著危险因素为：患者年龄较大（大于60岁）；PED面积较大（大于1个视盘直径）；黄斑区存在PED。随访期间感觉性视网膜脱离未减轻的眼发生NVM的风险显著较高。与未发生NVM的眼相比，发生NVM的眼视觉预后明显更差。生存分析（Kaplan-Meier法）显示，3个月时发生NVM的发生率为8%，6个月时为16%，9个月时为24%。这些结果表明，除患者年龄外，PED的大小和位置以及感觉性视网膜脱离的临床过程可能是PED预后的重要决定因素。
