VALBERG L S, WITTS L J
Gut. 1961 Mar;2(1):32-6. doi: 10.1136/gut.2.1.32.
A histamine test meal is described for the estimation of the secretion of gastric acid and pepsin in the unanaesthetized intact rat. The stomach of the rat secreted pepsin and a small amount of acid in response to the test meal of hypertonic sucrose. Stimulation with histamine produced a pronounced rise in acid secretion but the output of pepsin remained unchanged. The increase in acid secretion was correlated in the individual rat with a rise in the volume of gastric secretion. Histamine phosphate in a dose of 50 mg./kg. body weight produced maximal stimulation of gastric acid secretion and was free from toxic effects. Choline chloride, in a dose of 126.5 mg./kg. body weight, had no effect on the volume of gastric secretion and it was ineffective as a stimulant of either acid or pepsin secretion.
本文描述了一种用于评估未麻醉的完整大鼠胃酸和胃蛋白酶分泌的组胺试验餐。大鼠的胃对高渗蔗糖试验餐有反应，分泌胃蛋白酶和少量胃酸。用组胺刺激可使胃酸分泌显著增加，但胃蛋白酶的分泌量保持不变。在个体大鼠中，胃酸分泌的增加与胃分泌量的增加相关。剂量为50毫克/千克体重的磷酸组胺可产生最大程度的胃酸分泌刺激，且无毒性作用。剂量为126.5毫克/千克体重的氯化胆碱对胃分泌量没有影响，作为胃酸或胃蛋白酶分泌的刺激剂无效。
