Littman T, Kraus N, McGee T, Nicol T
Department of Communication Sciences, Northwestern University, Evanston, IL 60208.
Electroencephalogr Clin Neurophysiol. 1992 Jul-Aug;84(4):362-72. doi: 10.1016/0168-5597(92)90089-t.
Two morphologically distinct auditory middle latency response (MLR) wave forms can be recorded from the surface of the guinea pig brain. The temporal response is recorded from the temporal lobe contralateral to the stimulus ear, and the midline response is recorded over the posterior midline. Experimental evidence suggests that different neural generators contribute to the two responses. Furthermore, it appears that the temporal response principally reflects activity of the primary auditory pathway while the midline response reflects non-primary pathways. Although it is known that neurons throughout the auditory pathway exhibit distinct binaural interaction (BI) properties, thus far there have been no systematic attempts to differentiate the MLR wave forms in response to binaural stimulation. The purpose of this study was to determine if binaural click stimulation could functionally differentiate the midline and temporal MLR responses in the guinea pig. Binaural click stimulation caused a significant decrease in temporal MLR peak amplitudes, and a significant increase in midline MLR amplitudes. The fact that different BI patterns were observed suggests that the two MLR components are functionally distinct. The data further support the hypothesis that the midline and temporal MLR in guinea pigs reflect different neural generators and pathways.
从豚鼠脑表面可记录到两种形态上不同的听觉中潜伏期反应（MLR）波形。颞叶反应是从刺激耳对侧的颞叶记录的，中线反应是在后中线记录的。实验证据表明，不同的神经发生器对这两种反应有贡献。此外，似乎颞叶反应主要反映初级听觉通路的活动，而中线反应反映非初级通路的活动。虽然已知整个听觉通路中的神经元表现出不同的双耳相互作用（BI）特性，但迄今为止，还没有系统地尝试区分双耳刺激下的MLR波形。本研究的目的是确定双耳点击刺激是否能在功能上区分豚鼠的中线和颞叶MLR反应。双耳点击刺激导致颞叶MLR峰值振幅显著降低，中线MLR振幅显著增加。观察到不同的BI模式这一事实表明，两个MLR成分在功能上是不同的。这些数据进一步支持了豚鼠中线和颞叶MLR反映不同神经发生器和通路的假设。
