Autti-Rämö I, Gaily E, Granström M L
Department of Child Neurology, University of Helsinki, Finland.
Arch Dis Child. 1992 Jun;67(6):712-6. doi: 10.1136/adc.67.6.712.
The frequencies of 60 minor physical anomalies and various craniofacial measurements in 52 children with alcohol exposure of various durations in utero were determined and compared with 48 non-exposed healthy children at a mean age of 27 months. Compared with non-exposed children a significantly higher total minor physical anomaly count was observed in those children exposed prenatally to alcohol throughout pregnancy. Binge drinking was not associated with an increased minor physical anomaly count. During the first year of life facial features were judged according to subjective impression: 10 children had typical facial features of fetal alcohol syndrome (FAS) and 19 children were judged to have possible fetal alcohol effects on their face. Only six of them fulfilled the strict craniofacial criteria for diagnosis of FAS at the age of 27 months. Our results stress the importance of recognising also the subtle dysmorphic facial features associated with prenatal alcohol exposure: 22 of 29 (76%) of exposed children judged to have typical or possible features of FAS during the first year showed signs of central nervous system dysfunction at the age of 27 months.
测定了52名在子宫内不同时期接触酒精的儿童的60种轻微身体异常的频率和各种颅面测量数据，并与48名平均年龄为27个月的未接触酒精的健康儿童进行了比较。与未接触酒精的儿童相比，在整个孕期都产前接触酒精的儿童中观察到的轻微身体异常总数明显更高。暴饮并不与轻微身体异常数量的增加相关。在生命的第一年，根据主观印象对面部特征进行判断：10名儿童有胎儿酒精综合征（FAS）的典型面部特征，19名儿童被判断面部可能有胎儿酒精影响。在27个月大时，他们中只有6名符合FAS诊断的严格颅面标准。我们的结果强调了识别与产前酒精接触相关的细微畸形面部特征的重要性：在第一年被判断有FAS典型或可能特征的29名接触酒精儿童中，有22名（76%）在27个月大时出现了中枢神经系统功能障碍的迹象。
