Tennes K, Blackard C
Am J Obstet Gynecol. 1980 Dec 1;138(7 Pt 1):774-80. doi: 10.1016/s0002-9378(16)32735-1.
The effect of maternal alcohol consumption during pregnancy upon neonatal outcome was examined in 278 mother-infant dyads. Accounts of the mother's drug use as well as information about confounding factors were obtained by personal interviews on two occasions during pregnancy and again after delivery. The infants were examined by a standardized procedure for the presence of minor physical anomalies. Alcohol, in moderate amounts, was found to be unrelated to infant birth weight, birth length, or head circumference. Minor physical anomalies associated with fetal alcohol syndrome were no more common in infants exposed to heavy amounts of alcohol in the first trimester than in nonexposed infants. A weak but significant negative correlation between alcohol consumption and gestational age was not accounted for by covariance with emotional stress, parity, socioeconomic status, mother's age, or use of other drugs.
对278对母婴进行了研究，以考察孕期母亲饮酒对新生儿结局的影响。通过在孕期两次及产后再次进行的个人访谈，获取了母亲药物使用情况以及混杂因素的信息。采用标准化程序对婴儿进行检查，以确定是否存在轻微身体异常。发现适量饮酒与婴儿出生体重、身长或头围无关。与胎儿酒精综合征相关的轻微身体异常，在孕早期大量饮酒的婴儿中并不比未暴露婴儿更常见。饮酒量与孕周之间存在微弱但显著的负相关，这种相关性不能通过与情绪压力、产次、社会经济地位、母亲年龄或其他药物使用情况的协方差来解释。
