Periodic activity in cerebral arousal mechanisms--the relationship to sleep and brain damage.

Periodic activity during light sleep is well recognised in many physiological systems, particularly respiration. In damaged brains this activity can become exaggerated. It involves the autonomic nervous system, the muscles, the cerebrospinal fluid (CSF) pressure, the cerebral blood flow and the electroencephalogram (EEG). It is related to the level of arousal. The EEGs of 52 subjects were studied. In stage 0-1 sleep, periods of alpha activity alternated with periods of theta activity related to the level of arousal. The intervals between the alpha onsets were measured and the data pooled. There was a dominant interval of about 16 sec. It is suggested that this is a physiological cerebral rhythm involving the cortex and the brain-stem activating mechanisms, responsive to outside stimuli but essentially endogenous. It is related to the controls of the autonomic, motor, and some cerebral auto-regulatory mechanisms. It may be severely disturbed in brain damage.