Nakase H, Morimoto T, Tsunoda S, Sakaki T, Yabuno T, Kawai S, Ohnishi H, Hisanaga M, Nikaido Y
Department of Neurosurgery, Nara Medical University, Japan.
Neurol Med Chir (Tokyo). 1992 Apr;32(4):196-200. doi: 10.2176/nmc.32.196.
Cavernous angioma is a benign vascular hamartoma with an obscure etiology. Clinical, radiological, and histological features of 24 cases of cortical and subcortical cavernous angiomas were analyzed to investigate the etiology. The lesions were classified as hemorrhaging (8 cases) or non-hemorrhaging (16 cases) according to the initial symptom. Age, sex, location, calcification and postcontrast enhancement by computed tomography (CT), tumor staining by angiography, and calcification and hemosiderin by histological examination were analyzed. Multivariate analysis showed that calcification by CT and histological examination correlated with non-hemorrhaging cases. Histological examination showed that calcification occurred inside and outside the blood vessels, within the vessel walls and in the adjacent brain tissue. Hemosiderin was also seen in most cases. These findings suggest that cavernous angiomas without hemorrhage have a poor circulation, resulting in minor recurrent bleeding and thrombosis, as well as calcification.
海绵状血管瘤是一种病因不明的良性血管错构瘤。分析24例皮质和皮质下海绵状血管瘤的临床、放射学和组织学特征以探究病因。根据首发症状将病变分为出血性（8例）或非出血性（16例）。分析了年龄、性别、位置、计算机断层扫描（CT）的钙化及增强表现、血管造影的肿瘤染色以及组织学检查的钙化和含铁血黄素。多变量分析显示，CT和组织学检查的钙化与非出血性病例相关。组织学检查显示，钙化发生在血管内外、血管壁内及相邻脑组织中。多数病例也可见含铁血黄素。这些发现提示，无出血的海绵状血管瘤循环不良，导致轻微反复出血和血栓形成以及钙化。
