Smith F C, Shearman C P
University Department of Vascular Surgery, Queen Elizabeth Hospital, Birmingham, UK.
Agents Actions Suppl. 1992;37:251-7. doi: 10.1007/978-3-0348-7262-1_35.
A randomised placebo-controlled trial was conducted to investigate the effects of iloprost, a stable prostacyclin analogue, on peripheral resistance, graft blood flow and mean systemic arterial blood pressure (MABP) during femoro-crural arterial bypass. 3000ng of iloprost, infused into the graft, produced an immediate drop in peripheral resistance by a mean (range) of 40% (4-80%) (P less than 0.01, Wilcoxon). Decreased peripheral resistance persisted to 20 minutes. Graft flow during the same period increased by 52% (-7 to 294%) (P less than 0.01). A transient maximal drop in mean MABP of 22% from 83-65 mmHg occurred 5 minutes post iloprost infusion but caused no detrimental effects and recovered to baseline values by 10 mins. Iloprost produces an immediate decrease in peripheral resistance associated with a prolonged increase in graft blood flow. This may reduce graft failure in the early postoperative period.
进行了一项随机安慰剂对照试验，以研究稳定的前列环素类似物伊洛前列素在股腘动脉旁路移植术中对外周阻力、移植物血流量和平均体动脉血压（MABP）的影响。向移植物中输注3000ng伊洛前列素后，外周阻力立即平均下降40%（范围为4%-80%）（P<0.01，Wilcoxon检验）。外周阻力降低持续至20分钟。同期移植物血流量增加了52%（-7%至294%）（P<0.01）。伊洛前列素输注后5分钟，平均MABP从83 mmHg短暂最大下降22%至65 mmHg，但未产生有害影响，并在10分钟时恢复至基线值。伊洛前列素可使外周阻力立即降低，并使移植物血流量长期增加。这可能会减少术后早期移植物失败的情况。
