Hickey N C, Shearman C P, Crowson M C, Simms M H, Watson H R
Department of Surgery, Selly Oak Hospital, U.K.
Eur J Vasc Surg. 1991 Feb;5(1):19-22. doi: 10.1016/s0950-821x(05)80921-1.
A double-blind, randomised, placebo-controlled trial was conducted to study the effect of the stable prostacyclin analogue iloprost on femoro-distal graft blood flow. After completing femoro-distal reconstruction, 3000 ng of iloprost or placebo was injected into the graft over 2 min. Graft blood flow, measured by electromagnetic flowmetry, increased by a mean (range) of 94% (12 to 192%) in patients receiving iloprost (n = 15) compared to 6% (-34 to 53%) in controls (n = 16; p less than 0.0001, t-test). Increased graft flow, measured by duplex ultrasound, was maintained in the iloprost group over a 7 day period postoperatively (F = 5.2, p = 0.03; analysis of variance) and remained higher at 7 days (p = 0.007, t-test). Iloprost produces an immediate, sustained increase in graft blood flow after femoro-distal reconstruction and may therefore be of benefit in reducing the incidence of early graft failure.
进行了一项双盲、随机、安慰剂对照试验，以研究稳定的前列环素类似物伊洛前列素对股腘动脉移植物血流的影响。在完成股腘动脉重建后，将3000 ng伊洛前列素或安慰剂在2分钟内注入移植物。通过电磁血流仪测量，接受伊洛前列素治疗的患者（n = 15）的移植物血流平均增加（范围）94%（12%至192%），而对照组（n = 16）为6%（-34%至53%）（t检验，p < 0.0001）。通过双功超声测量，伊洛前列素组术后7天内移植物血流持续增加（F = 5.2，p = 0.03；方差分析），且在7天时仍较高（t检验，p = 0.007）。伊洛前列素在股腘动脉重建后可使移植物血流立即、持续增加，因此可能有助于降低早期移植物失败的发生率。
