Montorsi F, Galli L, Guazzoni G, Colombo R, Bulfamante G, Barbieri L, Matozzo V, Grazioli V, Rigatti P
Institute of Human Anatomy, University of Milan School of Medicine, Italy.
J Urol. 1992 Aug;148(2 Pt 1):321-5. doi: 10.1016/s0022-5347(17)36584-9.
Transrectal microwave hyperthermia of the prostate was administered to 191 patients with bladder outlet obstruction due to benign prostatic hyperplasia who were either at poor operative risk or who refused surgery. Patients were divided in 2 groups according to age and they underwent either 5 or 10, 60-minute sessions of hyperthermia, with a calculated intraprostatic temperature of 42.5 plus or minus 0.5C. Light and electron microscopy showed no irreversible damage at the glandular epithelium but did demonstrate a significant increase in neoformed intraprostatic capillary-like vessels. At 1, 12 and 24 months residual urine volume was significantly decreased in the majority of patients but only a minor amelioration of urinary flow rates and subjective symptoms was observed. According to maximum flow nomograms all patients were still obstructed postoperatively. Transrectal hyperthermia cannot be considered a genuine alternative to surgery for patients with bladder outlet obstruction due to benign prostatic hyperplasia.
对191例因良性前列腺增生导致膀胱出口梗阻、手术风险高或拒绝手术的患者进行经直肠前列腺微波热疗。根据年龄将患者分为两组，他们分别接受5次或10次、每次60分钟的热疗，计算得出前列腺内温度为42.5±0.5℃。光镜和电镜检查显示腺上皮无不可逆损伤，但新形成的前列腺内毛细血管样血管显著增加。在1个月、12个月和24个月时，大多数患者的残余尿量显著减少，但仅观察到尿流率和主观症状有轻微改善。根据最大尿流率列线图，所有患者术后仍存在梗阻。对于因良性前列腺增生导致膀胱出口梗阻的患者，经直肠热疗不能被视为手术的真正替代方法。
