链霉素和双氢链霉素引起的神经肌肉阻滞
Neuromuscular blockade by streptomycin and dihydrostreptomycin.
作者信息
JINDAL M N, DESHPANDE V R
出版信息
Br J Pharmacol Chemother. 1960 Dec;15(4):506-9. doi: 10.1111/j.1476-5381.1960.tb00271.x.
Abstract
Both streptomycin and dihydrostreptomycin in large doses produced neuromuscular blockade in different types of skeletal nerve-muscle preparations. Streptomycin had a quicker, more marked and a longer-lasting action than dihydrostreptomycin. Neostigmine reversed a partial block of streptomycin, but a complete neuromuscular block remained unaffected. Calcium ions antagonized the neuromuscular block of streptomycin rapidly but incompletely.
摘要
大剂量的链霉素和双氢链霉素均可在不同类型的骨骼肌神经-肌肉标本上产生神经肌肉阻滞。链霉素比双氢链霉素作用更快、更显著且持续时间更长。新斯的明可逆转链霉素所致的部分阻滞，但对完全性神经肌肉阻滞无影响。钙离子可迅速但不完全地对抗链霉素的神经肌肉阻滞作用。
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