Sayama K, Shiraishi S, Miki Y
Department of Dermatology, Ehime University School of Medicine, Japan.
Br J Dermatol. 1992 Jul;127(1):1-4. doi: 10.1111/j.1365-2133.1992.tb14814.x.
Immunohistochemical studies were performed to establish the distribution of membrane cofactor protein (MCP; CD46), decay-accelerating (DAF; CD55) and homologous restriction factor (HRF20; CD59), in normal skin appendages, and in benign and malignant skin neoplasms. At least two of these regulators were detected on normal eccrine glands, apocrine glands and sebaceous glands. They were also found in cellular naevi (CN), seborrhoeic keratoses (SK), basal cell carcinoma (BCC), Bowen's disease (BD), squamous cell carcinoma (SCC) and Paget's disease (PD). Although there were slight differences in their distribution, these regulators were found in all the cells examined, indicating that they are essential factors in human skin as well as other organs, and in neoplasms, in preventing autologous complement attack.
进行免疫组织化学研究以确定膜辅因子蛋白（MCP；CD46）、衰变加速因子（DAF；CD55）和同源限制因子（HRF20；CD59）在正常皮肤附属器、良性和恶性皮肤肿瘤中的分布。在正常的汗腺、顶泌汗腺和皮脂腺中检测到至少两种这些调节因子。它们也存在于细胞痣（CN）、脂溢性角化病（SK）、基底细胞癌（BCC）、鲍恩病（BD）、鳞状细胞癌（SCC）和佩吉特病（PD）中。尽管它们的分布存在细微差异，但在所有检测的细胞中都发现了这些调节因子，这表明它们是人类皮肤以及其他器官和肿瘤中防止自身补体攻击的重要因素。
