重新处理数据以形成质量调整生命年。
Reprocessing data to form QALYs.
作者信息
Coast J
机构信息
Department of Epidemiology and Public Health Medicine, University of Bristol.
出版信息
BMJ. 1992 Jul 11;305(6845):87-90. doi: 10.1136/bmj.305.6845.87.
OBJECTIVES
To determine whether reprocessing data from published sources into quality adjusted life years (QALYs), as recommended in The QALY Toolkit, is a useful method of helping purchasing authorities to determine the most cost effective pattern of care to buy for their populations.
SETTING
United Kingdom.
DESIGN
The method was tested for six elective surgical conditions; data from published studies were reprocessed into the Rosser index, to obtain values for change in quality of life. These were then used to form QALYs. A small validation exercise was carried out.
MAIN OUTCOME MEASURES
QALYs formed from the Rosser index.
RESULTS
Published data could not be found for three interventions (cataract surgery, inguinal hernia repair, varicose vein surgery). For the remainder (prostatectomy, hip replacement, and knee replacement) data were found which could be reprocessed to form QALYs, though it was often hard to compare data from different studies and many assumptions had to be made.
CONCLUSION
The value of QALY results obtained by this method is questionable, given the large number of assumptions which had to be made. For many interventions published data are unlikely to be available.
目的
按照《质量调整生命年工具包》中的建议，将已发表资料中的数据重新处理为质量调整生命年（QALY），以此判断这是否是一种有助于采购机构确定为其人群购买最具成本效益的护理模式的有用方法。
背景
英国。
设计
针对六种择期手术情况对该方法进行测试；将已发表研究中的数据重新处理为罗瑟指数，以获取生活质量变化值。然后用这些值来形成质量调整生命年。开展了一项小型验证工作。
主要观察指标
由罗瑟指数形成的质量调整生命年。
结果
未找到三种干预措施（白内障手术、腹股沟疝修补术、静脉曲张手术）的已发表数据。对于其余的（前列腺切除术、髋关节置换术和膝关节置换术），找到了可以重新处理以形成质量调整生命年的数据，不过通常很难比较不同研究的数据，且不得不做出许多假设。
结论
鉴于必须做出大量假设，通过该方法获得的质量调整生命年结果的价值值得怀疑。对于许多干预措施，不太可能获得已发表的数据。
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