Mottolese M, Vocaturo A, Bartolazzi A, Vocaturo G, Benevolo M, Sedati A, Atlante G, Prat M, Bigotti A, Natali P G
Department of Pathology, Regina Elena Cancer Institute, Rome, Italy.
Int J Cancer. 1992 Jul 30;51(6):869-72. doi: 10.1002/ijc.2910510606.
In the present study we have evaluated whether monoclonal antibodies (MAbs) B72.3 and AR-3 which display, on histological preparations, a differential reactivity with normal and transformed endometrium, could be a useful adjunct to endometrial cytology in the identification of pre-neoplastic and neoplastic conditions. Immunocytochemical (ICC) tests, using the 2 reagents, were performed on normal cycling endometrium and on hyperplastic and malignant lesions collected by the endocyte technique both from 86 surgically resected specimens and from 62 postmenopausal symptomatic and asymptomatic outpatients. The results obtained showed that the combination of the 2 MAbs can complement conventional morphology in the identification of pre-malignant atypical lesions and endometrial carcinoma of unclear cytological features, thus allowing a selection of those patients who are candidates for fractional curettage.
在本研究中，我们评估了单克隆抗体（MAbs）B72.3和AR-3在组织学制剂上对正常和转化子宫内膜显示出不同反应性，是否可作为子宫内膜细胞学的有用辅助手段，用于识别癌前和肿瘤性病变。使用这两种试剂进行免疫细胞化学（ICC）测试，对正常月经周期子宫内膜以及通过内吸技术从86例手术切除标本和62例绝经后有症状和无症状门诊患者收集的增生性和恶性病变进行检测。所得结果表明，这两种单克隆抗体的组合可在识别癌前非典型病变和细胞学特征不明确的子宫内膜癌方面补充传统形态学，从而能够筛选出适合分段刮宫的患者。
