Geppert M, Smyczek-Gargya B, Menton M
Universitäts-Frauenklinik Tübingen.
Zentralbl Gynakol. 1993;115(11):492-4.
Within 5 years 181 patients were diagnosed with grade I and grade II atypical hyperplasia (AH) in the curettage material of 4193 specimens at the University Department of Gynecology and Obstetrics in Tübingen. In 62.6% of grade I and in 38.8% of grade II AH, concomitant endometrial polyps were observed, rarely cystic alterations as well. Especially with AH grade II, most polyps exhibited epithelial proliferation. Plurifocality and in situ residuals of AH were seen (grade I 38.5%, grade II 77.3%). In the same time period 345 endometrial carcinomas were found. Due to embedding techniques and the observation that only approximately 60% of the cavum uteri surface is reached via curettage, diagnostic security is quite limited. It has been published that women with AH have a higher risk of developing endometrial carcinoma. A control curettage after 6 months or a wide indication for hysterectomy is recommended after atypical endometrial hyperplasia has been demonstrated.
在5年时间里，图宾根大学妇产科的4193份刮宫标本中，有181例患者被诊断为I级和II级非典型增生（AH）。在I级AH患者中，62.6%伴有子宫内膜息肉，在II级AH患者中，这一比例为38.8%，同时也很少见囊性改变。尤其是II级AH患者，大多数息肉表现为上皮增生。可见AH的多灶性和原位残留（I级为38.5%，II级为77.3%）。在同一时期，发现了345例子宫内膜癌。由于包埋技术以及通过刮宫只能触及约60%的子宫腔表面这一观察结果，诊断的安全性相当有限。据报道，患有AH的女性患子宫内膜癌的风险更高。在证实为非典型子宫内膜增生后，建议6个月后进行对照刮宫或广泛指征的子宫切除术。
