AIMAN R, CHAUDHARY N
Br J Pharmacol Chemother. 1959 Sep;14(3):377-9. doi: 10.1111/j.1476-5381.1959.tb00261.x.
The fall in blood sugar with carbutamide (BZ55) 24 hr. after the maintenance dose of insulin (28.1%+/-2.9 s.e) in rabbits made severely diabetic with alloxan was significantly different from the change in the blood sugar with the same drug given 72 hr. (6.8%+/-2.0) or distilled water given 24 hr. (7.7%+/-1.3) respectively after the last dose of insulin. It is postulated that the drug acts by liberating bound insulin in the plasma.
在给用四氧嘧啶造成严重糖尿病的家兔注射维持剂量胰岛素后24小时，卡布酰胺（BZ55）使血糖下降（28.1%±2.9标准误），这与在最后一剂胰岛素后72小时给予相同药物（6.8%±2.0）或24小时给予蒸馏水（7.7%±1.3）时血糖的变化显著不同。据推测，该药物通过释放血浆中结合的胰岛素起作用。
