口服抗糖尿病药物的作用机制。
Mechanism of action of oral antidiabetic drugs.
作者信息
AIMAN R, CHAUDHARY N
出版信息
Br J Pharmacol Chemother. 1959 Sep;14(3):377-9. doi: 10.1111/j.1476-5381.1959.tb00261.x.
Abstract
The fall in blood sugar with carbutamide (BZ55) 24 hr. after the maintenance dose of insulin (28.1%+/-2.9 s.e) in rabbits made severely diabetic with alloxan was significantly different from the change in the blood sugar with the same drug given 72 hr. (6.8%+/-2.0) or distilled water given 24 hr. (7.7%+/-1.3) respectively after the last dose of insulin. It is postulated that the drug acts by liberating bound insulin in the plasma.
摘要
在给用四氧嘧啶造成严重糖尿病的家兔注射维持剂量胰岛素后24小时，卡布酰胺（BZ55）使血糖下降（28.1%±2.9标准误），这与在最后一剂胰岛素后72小时给予相同药物（6.8%±2.0）或24小时给予蒸馏水（7.7%±1.3）时血糖的变化显著不同。据推测，该药物通过释放血浆中结合的胰岛素起作用。
相似文献
1
Mechanism of action of oral antidiabetic drugs.口服抗糖尿病药物的作用机制。
Br J Pharmacol Chemother. 1959 Sep;14(3):377-9. doi: 10.1111/j.1476-5381.1959.tb00261.x.
2
Action of carbutamide on isolated diaphragm of alloxan-diabetic rats.卡比脲对四氧嘧啶糖尿病大鼠离体膈肌的作用。
Metabolism. 1959 Sep;8:757-61.
3
[Studies on the hypoglycemic mechanism of BZ-55 (carbutamide) with reference to the metabolism of the drug itself].
Nihon Naibunpi Gakkai Zasshi. 1961 Mar 20;36:2013-34. doi: 10.1507/endocrine1927.36.12_2013.
4
[ORAL THERAPY OF DIABETES MELLITUS].[糖尿病的口服治疗]
Cas Lek Cesk. 1964 Mar 20;103:305-11.
5
[PRESENT STATUS OF DRUGS FOR THE ORAL THERAPY OF DIABETES MELLITUS].[糖尿病口服治疗药物的现状]
Sogo Rinsho. 1963 Oct;12:1933-40.
6
In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits.迷迭香（Rosmarinus officinalis）对四氧嘧啶诱导糖尿病兔抗糖尿病和抗氧化活性的体内评估
J Ethnopharmacol. 2008 Feb 28;116(1):64-73. doi: 10.1016/j.jep.2007.10.039. Epub 2007 Nov 4.
7
8
[VARIATIONS IN BLOOD SUGAR DURING PERFUSION OF THE ISOLATED LIVER OF ALLOXAN-DIABETIC RABBITS. STUDY OF THE ACTION OF INSULIN].[四氧嘧啶糖尿病兔离体肝脏灌注期间血糖的变化。胰岛素作用的研究]
C R Seances Soc Biol Fil. 1964;158:2169-73.
9
[POSSIBILITIES OF ORAL DIABETES THERAPY].
Ther Ggw. 1964 Jan;103:21-33.
10
Antihyperglycemic effect of the fruit-pulp of Eugenia jambolana in experimental diabetes mellitus.蒲桃果肉对实验性糖尿病的降血糖作用。
J Ethnopharmacol. 2006 Apr 6;104(3):367-73. doi: 10.1016/j.jep.2005.10.033. Epub 2006 Jan 18.
本文引用的文献
1
The effect of serum from insulin-resistant cases on the combination of insulin with the rat diaphragm.胰岛素抵抗患者血清对胰岛素与大鼠膈肌结合的影响。
J Clin Invest. 1952 Jan;31(1):107-10. doi: 10.1172/JCI102567.
2
Insulin in protein fractions of serum from healthy people and from insulin-treated diabetics.健康人和接受胰岛素治疗的糖尿病患者血清蛋白质组分中的胰岛素。
Lancet. 1958 Nov 8;2(7054):996-7. doi: 10.1016/s0140-6736(58)90482-3.
3
The effect of human plasma on the glucose uptake of the rat diaphragm before and after administration of carbutamide.服用甲磺丁脲前后，人血浆对大鼠膈肌葡萄糖摄取的影响。
Br J Pharmacol Chemother. 1957 Dec;12(4):475-8. doi: 10.1111/j.1476-5381.1957.tb00168.x.
4
Long-term studies of the sulfonylureas in totally depancreatized dogs.对完全胰腺切除的狗进行的磺脲类药物长期研究。
Ann N Y Acad Sci. 1957 Jul 10;71(1):170-6.
5
Insulin secretion following carbutamide injections in normal dogs.正常犬注射氨磺丁脲后的胰岛素分泌情况。
Proc Soc Exp Biol Med. 1956 Dec;93(3):539-42. doi: 10.3181/00379727-93-22811.
6
Insulin I-131 metabolism in man; plasma-binding, distribution and degradation.人体内胰岛素I-131的代谢；血浆结合、分布及降解
Am J Med. 1956 Sep;21(3):324-38. doi: 10.1016/0002-9343(56)90034-1.
7
Anterior pituitary growth hormone and blood sugar levels of normal and diabetic dogs.正常犬和糖尿病犬的垂体前叶生长激素及血糖水平
Am J Physiol. 1956 Jun;185(3):557-63. doi: 10.1152/ajplegacy.1956.185.3.557.
8
Insulin distribution and degradation.
Metabolism. 1956 Mar;5(2):128-37.
Zotero 插件