AIMAN R, KULKARNI R D
Br J Pharmacol Chemother. 1957 Dec;12(4):475-8. doi: 10.1111/j.1476-5381.1957.tb00168.x.
The glucose uptake of the rat diaphragm has been determined in the presence of the plasma of young volunteers before and after administration of carbutamide without and with added insulin. The increase in the glucose uptake of the rat diaphragm due to the added plasma above that in the medium alone has been termed plasma effect. The increase in the glucose uptake of the rat diaphragm with plasma and added insulin above that with only insulin in the medium has been termed plasma+insulin effect. There was a significant increase in the plasma effect and the plasma+insulin effect after carbutamide administration. The increase in the plasma+insulin effect was significantly greater than the increase in the plasma effect. From these observations it has been suggested that carbutamide potentiates the action of insulin peripherally. Observed facts about carbutamide do not contradict this mechanism of action.
在年轻志愿者服用卡比马嗪前后，分别在无添加胰岛素和添加胰岛素的情况下，测定了大鼠膈肌对葡萄糖的摄取。因添加血浆而导致大鼠膈肌葡萄糖摄取量相对于仅在培养基中的摄取量增加，这被称为血浆效应。与仅在培养基中添加胰岛素相比，添加血浆和胰岛素时大鼠膈肌葡萄糖摄取量的增加被称为血浆+胰岛素效应。服用卡比马嗪后，血浆效应和血浆+胰岛素效应均显著增加。血浆+胰岛素效应的增加显著大于血浆效应的增加。基于这些观察结果，有人提出卡比马嗪在外周增强胰岛素的作用。关于卡比马嗪的观察事实并不与这种作用机制相矛盾。
