Hisajima H, Saito H, Abe K, Nishiyama N
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
J Neurosci Res. 1992 Mar;31(3):549-53. doi: 10.1002/jnr.490310319.
Effects of human recombinant acidic fibroblast growth factor (haFGF) on long-term potentiation (LTP) and the increase of the spike amplitude induced by weak tetanic stimulation were investigated and compared with those of CS23 (modified human basic FGF) in the dentate gyrus of fasted and nonfasted rats. haFGF didn't influence the LTP induced by the tetanus of 100 pulses at 100 Hz in both 24 hr fasted and non-fasted rats. On the other hand, the tetanus of 20 pulses at 60 Hz significantly enhanced the amplitude of population spike and facilitated the generation of LTP by the i.c.v. injection of 10 microliters of 20-40 micrograms/ml haFGF in 24 hr fasted rats but not in non-fasted rats. However, 40 micrograms/ml CS23 induced LTP when the tetanus of 20 pulses at 60 Hz was applied in both fasted and non-fasted states. These results suggest that haFGF might be one of the regulating factors of feeding and memory.
研究了人重组酸性成纤维细胞生长因子（haFGF）对长时程增强（LTP）以及弱强直刺激诱导的峰电位幅度增加的影响，并在禁食和未禁食大鼠的齿状回中将其与CS23（修饰的人碱性FGF）的作用进行了比较。在禁食24小时和未禁食的大鼠中，haFGF均不影响100Hz 100个脉冲的强直刺激诱导的LTP。另一方面，在禁食24小时的大鼠中，60Hz 20个脉冲的强直刺激通过脑室内注射10微升20-40微克/毫升的haFGF可显著增强群体峰电位的幅度并促进LTP的产生，但在未禁食的大鼠中则不然。然而，在禁食和未禁食状态下，当施加60Hz 20个脉冲的强直刺激时，40微克/毫升的CS23均可诱导LTP。这些结果表明，haFGF可能是进食和记忆的调节因子之一。
