Llorens J, Tusell J M, Suñol C, Rodríguez-Farré E
Department of Neurochemistry, Consejo Superior de Investigaciones Cientificas (CSIC), Barcelona, Spain.
Toxicol Lett. 1992 Jul;61(2-3):265-74. doi: 10.1016/0378-4274(92)90153-b.
Male Wistar rats were given 25 doses of lindane, 10 mg/kg per day, 1 ml/kg p.o. in olive oil, or control vehicle. Two weeks after the last dose, the animals were assessed for modifications in spontaneous motor activity, plus-maze behavior, shuttle-box active avoidance acquisition, brain regional concentrations of biogenic amines and metabolites, and regional [35S]TBPS binding. Rats treated with lindane showed an increase in spontaneous motor activity. Although no additional behavioral or neurochemical modifications were found, the changes in activity observed at 2 weeks post-exposure further demonstrate the need to assess for long lasting neurobehavioral sequelae of repeated lindane exposure.
雄性Wistar大鼠每天经口给予25剂林丹，剂量为10毫克/千克，溶于橄榄油中，每千克1毫升，或给予对照赋形剂。末次给药两周后，评估动物的自发运动活动、十字迷宫行为、穿梭箱主动回避习得、脑区生物胺和代谢物浓度以及脑区[35S]TBPS结合的变化。用林丹处理的大鼠自发运动活动增加。虽然未发现其他行为或神经化学变化，但暴露后2周观察到的活动变化进一步表明，有必要评估反复接触林丹后的长期神经行为后遗症。
