Rivera S, Sanfeliu C, Rodríguez-Farré E
Department of Pharmacology and Toxicology, CSIC, Spain.
Neurotoxicol Teratol. 1990 Nov-Dec;12(6):591-5. doi: 10.1016/0892-0362(90)90067-m.
The purpose of this study was to determine whether the behavioral developmental pattern was altered by an early postnatal exposure to lindane. Male and female offspring of Wistar rats were daily orally administered with a nonconvulsant dose of lindane (10 mg/kg) during 7 days either the 1st or the 2nd postnatal week days. Effects on pups were evaluated with a reduced developmental neurotoxicological test battery. Body weight evolution, neuromotor reflexes (surface righting, cliff avoidance and tail hang reflex) and spontaneous motor activity were analyzed from day 1 after birth up to day 28. The body weight pattern was unaffected by treatment with lindane and no signs of overt toxicity were observed. Lindane-treated pups showed an increased positive response of the neuromotor reflexes. Furthermore, lindane produced hyperactivity, especially manifested between days 12 and 16. A peak of activity was reached at day 16 in lindane-treated group, while control animals had a maximum between days 20 and 24. These results suggest that low nonconvulsant doses of lindane may induce behavioral changes in developing rats.
本研究的目的是确定出生后早期接触林丹是否会改变行为发育模式。在出生后的第1周或第2周，对Wistar大鼠的雄性和雌性后代每天口服非惊厥剂量的林丹（10毫克/千克），持续7天。采用简化的发育神经毒理学测试组合评估对幼崽的影响。分析从出生后第1天到第28天的体重变化、神经运动反射（表面翻正、避崖和悬尾反射）以及自发运动活动。林丹处理对体重模式没有影响，也未观察到明显的毒性迹象。经林丹处理的幼崽神经运动反射的阳性反应增加。此外，林丹导致多动，尤其在第12天至第16天表现明显。林丹处理组在第16天达到活动峰值，而对照组动物在第20天至第24天达到活动最大值。这些结果表明，低非惊厥剂量的林丹可能会诱导发育中的大鼠出现行为变化。
