Kiremidjian-Schumacher L, Roy M, Wishe H I, Cohen M W, Stotzky G
New York University, Dental Center, Department of Oral Medicine and Pathology, N.Y. 10010.
Biol Trace Elem Res. 1992 Apr-Jun;33:23-35. doi: 10.1007/BF02783989.
Selenium (Se) is an essential nutritional factor that affects the development and expression of cell-mediated immune responses directed toward malignant cells. These studies have shown that dietary (2 ppm for 8 wk) or in in vitro (1 x 10(-7)M) supplementation with Se (as sodium selenite) results in a significant enhancement of the proliferative responses of spleen lymphocytes from C57Bl/6J mice in response to stimulation with mitogen or antigen. Se deficiency (0.02 ppm for 8 wk) had the opposite effect. The alterations in the ability of the cells to proliferate, which occurred in the absence of changes in the endogenous levels of interleukin-2 (Il2) or interleukin 1, were apparently related to the ability of Se to alter the kinetics of expression of high-affinity Il2 receptors on the surface of activated lymphocytes. This resulted in an enhanced or delayed clonal expansion of the cells, and in an increased or decreased frequency of cytotoxic cells within a given cell population. The changes in tumor cytotoxicity were paralleled by changes in the amounts of lymphotoxin produced by the activated cells. Dietary Se modulations had a comparable effect on macrophage-mediated tumor cytodestruction. The results also suggested that Se exerts its effect 8-24 h after stimulation, and that it most likely affects processes in the cytoplasmic and/or nuclear compartments of activated lymphocytes.
硒（Se）是一种必需的营养因子，它影响针对恶性细胞的细胞介导免疫反应的发育和表达。这些研究表明，饮食中补充硒（以亚硒酸钠形式，2 ppm，持续8周）或体外补充（1×10⁻⁷M）会显著增强C57Bl/6J小鼠脾淋巴细胞在有丝分裂原或抗原刺激下的增殖反应。缺硒（0.02 ppm，持续8周）则产生相反的效果。细胞增殖能力的改变，在白细胞介素-2（Il2）或白细胞介素1内源性水平没有变化的情况下发生，显然与硒改变活化淋巴细胞表面高亲和力Il2受体表达动力学的能力有关。这导致细胞克隆扩增增强或延迟，以及给定细胞群体中细胞毒性细胞的频率增加或减少。肿瘤细胞毒性的变化与活化细胞产生的淋巴毒素量的变化平行。饮食中硒的调节对巨噬细胞介导的肿瘤细胞破坏有类似的影响。结果还表明，硒在刺激后8 - 24小时发挥作用，并且很可能影响活化淋巴细胞的细胞质和/或细胞核区室中的过程。
