Abel H T, Korb C, Meder S, Lamme W, Köditz H
Frühgeborenenzentrum, Medizinischen Akademie Magdeburg.
Kinderarztl Prax. 1992 Jun;60(4-5):142-6.
In a prospective study the psychomotor development up to the end of the second year of life of 409 preterm and term newborn infants was examined in order to identify which optimality score might be associated with disturbances of normal childlike development. Significant connections between 24 and 55 risk factors and the mortality could be demonstrated, but only 3 factors (sex, apgar, acidosis) exert influence on psychomotor development. The risk loading of the collective was high, not one of the children showed an optimal score. Decreased patients possessed a stronger reduced optimality than survivors. The optimality concept is not suitable for the prediction of later disturbed development of children, because the items are unspecific. The marker of hypoxia, the erythrocytic-density-test, as well as the neuron-specific enolase showed better diagnostic values than the optimality concept.
在一项前瞻性研究中，对409名早产和足月新生儿至两岁末的心理运动发育进行了检查，以确定哪种最优性评分可能与正常儿童发育障碍相关。可以证明24至55个风险因素与死亡率之间存在显著关联，但只有3个因素（性别、阿氏评分、酸中毒）对心理运动发育有影响。总体的风险负荷很高，没有一个孩子表现出最优评分。病情加重的患者比幸存者的最优性降低得更明显。最优性概念不适用于预测儿童后期的发育障碍，因为这些项目不具有特异性。缺氧标志物、红细胞密度试验以及神经元特异性烯醇化酶比最优性概念具有更好的诊断价值。
