Chen J, Borden P, Liao J, Kabat E A
Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York 10032.
Mol Immunol. 1992 Sep;29(9):1121-9. doi: 10.1016/0161-5890(92)90045-y.
The variables regions of three syngeneic anti-idiotypic antibodies (Ab2s) were cloned and sequenced. They are encoded by different VL genes, two are from different members of V kappa-Ox1 superfamily. The H chains are encoded by VH genes belonging to three different VH families, J558, Q52 and 7183. Together with a previous report from this laboratory, the nucleotide sequences of four Ab2s to anti-alpha(1----6)dextrans have been presented. They are derived from a number of unrelated germline genes, and differ from similar studies in anti-NP, anti-GAT and anti-Ars systems. Three of four Ab2s in the anti-alpha(1----6)dextran system appear to have D-D fusions, which has also been reported in several other Ab2s.
克隆并测序了三种同基因抗独特型抗体（Ab2）的可变区。它们由不同的VL基因编码，其中两个来自Vκ-Ox1超家族的不同成员。重链由属于三个不同VH家族J558、Q52和7183的VH基因编码。连同本实验室之前的一份报告，已给出了四种抗α（1→6）葡聚糖Ab2的核苷酸序列。它们源自许多不相关的种系基因，与抗NP、抗GAT和抗Ars系统的类似研究不同。抗α（1→6）葡聚糖系统中的四种Ab2中有三种似乎存在D-D融合，这在其他几种Ab2中也有报道。
