Elsaghier A, Lathigra R, Ivanyi J
MRC Tuberculosis and Related Infections Unit, Royal Postgraduate Medical School, London, UK.
Mol Immunol. 1992 Sep;29(9):1153-6. doi: 10.1016/0161-5890(92)90049-4.
Four distinct linear epitopes localized within species-specific sequences at the carboxy-terminal end of the 71 kDa heat shock protein of M. tuberculosis have been identified by scanning 94 overlapping peptides with 13 human sera. One epitope ("C") of entirely M. tuberculosis-specific core sequence (GEAGPG) has been found immunogenic in smear-negative tuberculosis, but not in non-tuberculous mycobacterial diseases. This peptide appears to be a valuable candidate for further serodiagnostic evaluation.
通过用13份人血清扫描94个重叠肽段，已在结核分枝杆菌71 kDa热休克蛋白羧基末端的种特异性序列中鉴定出4个不同的线性表位。已发现一个完全由结核分枝杆菌特异性核心序列（GEAGPG）组成的表位（“C”）在涂片阴性肺结核中具有免疫原性，但在非结核分枝杆菌疾病中则不然。该肽段似乎是进一步进行血清学诊断评估的有价值候选物。
