Mirrakhimov M M, Iusupova N Ia
Kardiologiia. 1975 Oct;15(10):39-45.
In patients with mitral lesions and prevalence of stenosis and insufficient circulation of the I, II A and B stages clinical and functional indicators of the cardiac work were studied at three different altitudes, viz. with a low-mountain relief (760 m), middle-mountain relief (1650-2020 m) and in highland (3600-4200 m). In highland decompensated mitral incompetence was found to be characterized by a much higher incidence of such manifestations of the disease as vertigo, syncopal attacks, fits of distressed respiration, epigastral pulsation, positive venous pulse, a significant expansion of the heart to the right, accentuation and splitting of the II tone on the pulmonary artery, overloading of the right ventricle and atrium (according to ECG findings), the absence of peripheral edematization and fibrillation arrythmia, the presence of arterial and venous hypotension, highly intensive hyperventilation, a drop of PAO2 and PACO2. In patients-residents of low- and middle-mountain regions the severity of clinical and hemodynamic disorders depended on the stage of cardiac insufficiency, whereby in residents of the second region the disclosed deviations on the level of circulation proved more marked. It is shown that the correlation links between individual physiological variables become greatly disrupted parallel with progressively increasing severity of cardiac incompetence. In conditions prevailing in the middle and, especially, high altitude areas there are evident links between individual functional indicators which are absent in low-mountain areas. The above data bear evidence not only to the fact that with progressive severity of cardiac insufficiency the disrupted regulation of the circulation system becomes still more aggravated, but also to the presence of other compensatory mechanisms that are operative in mountain areas.
在患有二尖瓣病变且处于I、II A和B期狭窄及循环不足的患者中,研究了心脏工作的临床和功能指标,研究是在三个不同海拔高度进行的,即低山地形(760米)、中山地形(1650 - 2020米)和高原(3600 - 4200米)。发现在高原地区,失代偿性二尖瓣关闭不全的特点是该疾病的此类表现发生率更高,如眩晕、晕厥发作、呼吸窘迫发作、上腹部搏动、阳性静脉搏动、心脏显著向右扩大、肺动脉第二心音亢进和分裂、右心室和心房负荷过重(根据心电图结果)、无外周水肿和房颤心律失常、存在动脉和静脉低血压、高度强烈的过度通气、动脉血氧分压和动脉血二氧化碳分压下降。在低山和中山地区的居民患者中,临床和血流动力学紊乱的严重程度取决于心脏功能不全的阶段,由此在第二个地区的居民中,所发现的循环水平偏差更为明显。结果表明,随着心脏功能不全严重程度的逐渐增加,个体生理变量之间的相关联系受到极大破坏。在中山地区尤其是高原地区普遍存在的条件下,个体功能指标之间存在明显联系,而在低山地区则不存在。上述数据不仅证明随着心脏功能不全严重程度的加重,循环系统调节紊乱变得更加严重,而且还证明在山区存在其他起作用的代偿机制。