Iusupova N Ia, Kudaĭberdiev E M, Narbekov O N
Kardiologiia. 1976 Jun;16(6):121-5.
A clinical study was conducted in 236 patients with decompensated mitral valve disease--permanent residents of the areas located at various altitudes in the Pamirs and Tien Shan (760 to 4,200 m above the sea level). The main parameters of haemodynamics were studied by means of the dye dilution method in 158 of them, as well as the indices of cardiodynamics by way of polycardiography. The data obtained in 120 normal individuals living in foothills (760 m) served as control. It was demonstrated that with the same stages of cardiac insufficiency, the most striking changes in the haemo- and cardiodynamics were noted among the residents of the high altitude areas. Among those living at medium altitudes (1,650 to 2,020 m), the cardiac output and the left ventricular function appeared to be reduced most distinctly. These patients also exhibited a clear relationship between the main variables of the cardiovascular functions and the severity of cardiac insufficiency. The revealed clinical and functional peculiarities of the decompensated mitral valve disease in mountaneers are atrributable to the effect of hypoxic hyposy upon the regulation of the respiration and the pulmonary circulation.
对236例失代偿性二尖瓣疾病患者进行了一项临床研究，这些患者是帕米尔高原和天山不同海拔地区（海拔760米至4200米）的常住居民。其中158例患者采用染料稀释法研究了血流动力学的主要参数，并通过多心电图法研究了心脏动力学指标。以生活在山麓地区（760米）的120名正常人的数据作为对照。结果表明，在相同的心功能不全阶段，高海拔地区居民的血流动力学和心脏动力学变化最为显著。在中等海拔地区（1650米至2020米）生活的人群中，心输出量和左心室功能下降最为明显。这些患者的心血管功能主要变量与心功能不全的严重程度之间也存在明显关系。登山者失代偿性二尖瓣疾病所表现出的临床和功能特点归因于低氧血症对呼吸和肺循环调节的影响。
