Henken D B, Martin J R
Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Neurosci Lett. 1992 Jun 22;140(2):177-80. doi: 10.1016/0304-3940(92)90096-p.
To investigate whether neurobiological functions are modified by viral infection, we inoculated mouse corneas with herpes simplex virus type 1 (HSV-1) and examined neuronal galanin content in trigeminal ganglia at selected survival times. HSV-1 antigen appeared in neurons at day 3, peaked at day 6 and disappeared by day 11. Increased galanin positivity was first seen at day 6, peaked at day 10 and approached control values by day 21. This result provides further evidence that the biological program of peripheral sensory neurons is modified by herpes-virus infection.
为了研究神经生物学功能是否会因病毒感染而发生改变，我们用1型单纯疱疹病毒（HSV-1）接种小鼠角膜，并在选定的存活时间检查三叉神经节中神经元甘丙肽的含量。HSV-1抗原在第3天出现在神经元中，在第6天达到峰值，并在第11天消失。甘丙肽阳性增加首先在第6天出现，在第10天达到峰值，并在第21天接近对照值。这一结果进一步证明外周感觉神经元的生物学程序会因疱疹病毒感染而改变。
