细胞角蛋白在颗粒细胞瘤和卵巢癌中的表达。

Expression of cytokeratins in granulosa cell tumors and ovarian carcinomas.

作者信息

Gitsch G, Kohlberger P, Steiner A, Neumeister B, Breitenecker G

机构信息

Second Department of Obstetrics and Gynecology, University and Medical School, Vienna, Austria.

出版信息

Arch Gynecol Obstet. 1992;251(4):193-7. doi: 10.1007/BF02718386.

DOI:10.1007/BF02718386

PMID:1380231

Abstract

One of the problems in histopathology of ovarian tumors is differential diagnosis between the poorly differentiated carcinomas and granulosa cell tumors of the sarcomatoid type. Hence we evaluated the expression of various cytokeratins (CK 1-19; CK 10, 13, 14, 15, 19; CK 8, 18, 19; CK HMW 1, 5, 10, 11; CK 8; CK 1-19 Stähli; CK AE1/AE3) immunohistochemically in 53 ovarian malignancies (11 of them poorly differentiated carcinomas and 12 granulosa cell tumors). CK HMW was not detected in granulosa cell tumors, and in only half of the carcinomas. AE1/AE3 was expressed by more than 90% of ovarian carcinomas but by one granulosa cell tumor only. The other keratins we investigated showed higher expression rates in granulosa cell tumors and/or lower expression rates in ovarian carcinomas. We think that cytokeratin immunohistochemistry is of value in differentiating between granulosa cell tumors and ovarian carcinomas.

摘要

卵巢肿瘤组织病理学中的一个问题是鉴别低分化癌和肉瘤样型颗粒细胞瘤。因此，我们采用免疫组织化学方法评估了53例卵巢恶性肿瘤（其中11例为低分化癌，12例为颗粒细胞瘤）中各种细胞角蛋白（CK 1 - 19；CK 10、13、14、15、19；CK 8、18、19；CK HMW 1、5、10、11；CK 8；CK 1 - 19 Stähli；CK AE1/AE3）的表达情况。颗粒细胞瘤中未检测到CK HMW，仅在半数的癌组织中检测到。超过90%的卵巢癌表达AE1/AE3，而颗粒细胞瘤中只有1例表达。我们研究的其他角蛋白在颗粒细胞瘤中的表达率较高和/或在卵巢癌中的表达率较低。我们认为细胞角蛋白免疫组织化学在鉴别颗粒细胞瘤和卵巢癌方面具有价值。