Miettinen M, Lehto V P, Virtanen I
Int J Gynecol Pathol. 1983;2(1):64-71. doi: 10.1097/00004347-198301000-00006.
The presence of different types of intermediate filaments (IMF) was studied in normal ovarial tissue and in ovarian tumors. The coelomic epithelium contained both prekeratin and vimentin, but the graafian follicle cells and stromal cells contained only vimentin. In normal ovaries, desmin positivity was confined to the arterial walls. Tumors derived from surface epithelium, including Brenner tumors, expressed prekeratin in the epithelial cells, whereas sex cord-stromal tumors showed only vimentin-type IMF. Germinal tumors also showed only vimentin-type IMF, whereas differentiated teratomas expressed the IMF of the corresponding differentiation line, as recognized by light microscopy. Thus, the skin, skin appendages, and other epithelial components of dermoid cysts showed prekeratin; mesenchymal components showed vimentin (but smooth muscle cells, desmin), and glial-like areas showed glial fibrillary acidic protein. The results suggest that expression of IMF in ovarian tumors corresponds to the filament expression of the parental tissues and that the typing of IMF can be used in the differential diagnosis between ovarian tumors of different histogenesis.
研究了正常卵巢组织和卵巢肿瘤中不同类型中间丝（IMF）的存在情况。体腔上皮同时含有前角蛋白和波形蛋白，但格拉夫卵泡细胞和基质细胞仅含有波形蛋白。在正常卵巢中，结蛋白阳性仅限于动脉壁。源自表面上皮的肿瘤，包括 Brenner 瘤，上皮细胞中表达前角蛋白，而性索间质肿瘤仅显示波形蛋白型 IMF。生殖细胞肿瘤也仅显示波形蛋白型 IMF，而分化型畸胎瘤表达相应分化谱系的 IMF，这在光学显微镜下是可以识别的。因此，皮样囊肿的皮肤、皮肤附属器和其他上皮成分显示前角蛋白；间充质成分显示波形蛋白（但平滑肌细胞显示结蛋白），胶质样区域显示胶质纤维酸性蛋白。结果表明，卵巢肿瘤中 IMF 的表达与亲代组织的丝蛋白表达相对应，并且 IMF 的分型可用于不同组织发生的卵巢肿瘤的鉴别诊断。
