Krstić M K, Stepanović R M, Vucković S M, Krstić S K
Department of Pharmacology, Faculty of Medicine, Belgrade, Yugoslavia.
Arch Int Physiol Biochim Biophys. 1992 Jan-Feb;100(1):101-3. doi: 10.3109/13813459209035267.
The mechanism of histamine-induced relaxation in the isolated rat common carotid artery was analysed. Histamine (3 x 10(-7)-10(-4) mol/l) caused a concentration-dependent relaxation of the artery. Indomethacin, a cyclo-oxygenase inhibitor, and diethylcarbamazine, a lipoxygenase inhibitor, did not affect the relaxant response of the artery to histamine. After removal of the vascular endothelium the histamine-induced relaxation was strongly reduced. Moreover, hemoglobin and methylene blue, inhibitors of endothelium-derived relaxing factor (EDRF), prevented or reversed the relaxant effect of histamine. These findings confirm that the histamine-induced relaxation is to a greater extent endothelium dependent. It is concluded that the endothelium-dependent component in the relaxant response of the rat common carotid artery to histamine results from the release of EDRF.
分析了组胺诱导离体大鼠颈总动脉舒张的机制。组胺（3×10⁻⁷ - 10⁻⁴mol/L）引起动脉浓度依赖性舒张。环氧化酶抑制剂吲哚美辛和脂氧化酶抑制剂乙胺嗪不影响动脉对组胺的舒张反应。去除血管内皮后，组胺诱导的舒张作用明显减弱。此外，内皮源性舒张因子（EDRF）抑制剂血红蛋白和亚甲蓝可阻止或逆转组胺的舒张作用。这些发现证实组胺诱导的舒张在很大程度上依赖于内皮。得出结论，大鼠颈总动脉对组胺舒张反应中的内皮依赖性成分是由EDRF释放所致。
