Krstić M K, Stepanović R M, Krstić S K, Katusić Z S
Department of Pharmacology, Faculty of Medicine, Belgrade, Yugoslavia.
Arch Int Physiol Biochim. 1988 Dec;96(5):197-200. doi: 10.3109/13813458809075944.
The effect of histamine on the isolated rat common carotid, renal and cranial mesenteric arteries was examined. Histamine (10(-8)-10(-4) M) caused concentration-dependent relaxations of the arteries during contractions induced with phenylephrine (10(-8)-10(-7) M). Removal of the vascular endothelium inhibited the histamine-induced relaxations. Pyrilamine (6 X 10(-6) M), but not metiamide (10(-6) M), abolished the relaxant effect of histamine. Moreover, pyrilamine (6 X 10(-6) M) did not affect endothelium-dependent relaxations of the arteries produced with acetylcholine. These results indicate that histamine causes endothelium-dependent relaxations of the rat peripheral large conduit arteries, which appeared to be mediated via H1-histaminergic receptors.
研究了组胺对离体大鼠颈总动脉、肾动脉和肠系膜上动脉的作用。组胺（10⁻⁸ - 10⁻⁴ M）在去氧肾上腺素（10⁻⁸ - 10⁻⁷ M）诱导的收缩过程中引起动脉的浓度依赖性舒张。去除血管内皮可抑制组胺诱导的舒张。吡苄明（6×10⁻⁶ M）而非甲硫咪特（10⁻⁶ M）可消除组胺的舒张作用。此外，吡苄明（6×10⁻⁶ M）不影响乙酰胆碱引起的动脉内皮依赖性舒张。这些结果表明，组胺可引起大鼠外周大传导动脉的内皮依赖性舒张，这似乎是通过H1组胺能受体介导的。
